Hello JAZ_MN,
Welcome to the HP Forums!
I understand your Officejet 6500 is not communicating with the computer anymore. I will do my best to assist! Please make sure this printer is set as default:
1) Click on the Start Menu
2) Click on Devices and Printers
3) Let me know if you have one or more Officejet 6500 in here
4) If you have one printer, then right click on the printer
5) Make sure you set as default Officejet 6500 (Not Fax)
I realize you're using a USB port on a hub. Please make sure the USB cord is plugged into a 2.0, not 3.0. I would recommend following this HP document on 'The Computer Is Unable to Establish a Two-Way Communication with the USB Device' Message Displays on the Computer.
Please post your results! :smileyhappy: